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Most of the adenosine triphosphate (ATP) synthesized during glucose metabolism is produced in the mitochondria through oxidative phosphorylation. This is a complex reaction powered by the proton gradient across the mitochondrial inner membrane, which is generated by mitochondrial respiration.Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by cytosolic ADP. We discuss mitochondrial Ca 2+ signaling and its dysfunction which has recently been linked to cardiac pathologies including arrhythmia and heart failure.In the human heart, the energy supplied by the production of ATP is predominately accomplished by ß-oxidation in mitochondria, using fatty acids (FAs) as the primary fuel. Long-chain acylcarnitines (LCACs) are intermediate forms of FA transport. Atp production in mitochondria.

pubmed.ncbi.nlm.nih.gov › 16945388 A simplified model for mitochondrial ATP production

  1. www.ncbi.nlm.nih.gov › pmc › articles Long-Chain Acyl-Carnitines Interfere with Mitochondrial ATP
  2. www.sciencedirect › science › article A simplified model for mitochondrial ATP production
  3. pubmed.ncbi.nlm.nih.gov › 31767352 Regulation of Mitochondrial ATP Production: Ca 2+ Signaling
  4. themitochondria.weebly › atp-production ATP Production - The Mitochondria