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www.mayoclinic.org › antidepressants › faq-20057938 Antidepressants: Can they stop working? - Mayo Clinic

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Antidepressants are usually taken daily. The goal in the first few weeks and months is to relieve the symptoms and, where possible, make the depressiongo away. Once that has been achieved, the treatment is continued for at least four to nine months. This continuation therapy is necessary to stop the symptoms from coming back.It never occurred to me that the Zoloft just wasn't working anymore until I discovered on several forums that many depression sufferers also had an experience with Zoloft losing it's effectiveness over time. My plan is to go to my doctor and switch to a new medication.Zoloft is the first antidepressant I've tried with a clearly useful effect for Persistent Depressive Disorder, and I'm about to change from 50 to 25 mg. I believe the effects are very dependent on the individual, so you just need to try for yourself. 50 mg Zoloft: significant effect (removal of severe emotional lows).Answer From Daniel K. Hall-Flavin, M Zoloft effectiveness over time.D. When depression symptoms improve after starting an antidepressant, many people need to continue taking medication long term to prevent symptoms from returning. However, in some people, a particular antidepressant may simply stop working over time.Assuming dosage is properly titrated, Zoloft should begin working for most recipients in under 8 weeks (some may notice a quicker effect than others). Only a small percentage of users administering therapeutically-relevant doses of Zoloft will require more than 8 weeks to notice an effect. Zoloft effectiveness over time.

www.ncbi.nlm.nih.gov › books › NBK361016 Depression: How effective are antidepressants

  1. www.ncbi.nlm.nih.gov › books › NBK361016 Depression: How effective are antidepressants
  2. www.drugs › answers › find-zoloft-loses Anybody else find that Zoloft loses effectiveness after a while?
  3. mentalhealthdaily › 2018/03/10 › how-long- How Long Does It Take For Zoloft To Work or "Kick In
  4. www.ncbi.nlm.nih.gov › books › NBK361016 Depression: How effective are antidepressants